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Breast cancer is the most frequent form of cancer among women and still represents a major cause of death in women due to cancer. Breast cancer develops from atypical hyperplasia, a premalignant lesion that, via ductal carcinoma in situ DCIS progresses to invasive carcinoma with varying metastatic potential. This process is believed to be driven by successive mutations as predicted by the multistep carcinogenesis model [ 1 , 2 ]. Following this model distinct gene expression profiles are expected to be associated with the different stages of cancer development.
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The process of entering the bloodstream, intravasation, is a necessary step in the development of distant metastases. local news matters.
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